Preparation of 3,6-difluoro- and 3-chlorofluoropyridazines and their nucleophilic reactions was written by Ishikawa, Nobuo;Kuroda, Katsuhiko;Onodera, Nobuo. And the article was included in Kogyo Kagaku Zasshi in 1971.Related Products of 33097-39-1 This article mentions the following:
3,6-Dichloropyridazine was treated with KF in DMF to give 3-fluoro-6-chloropyridazine (I) which was further treated with KF in Me2SO to give 3,6-difluoropyridazine (II). Treatment of II with 1 mole of various phenols (PhOH, o-, m-, p-ClC6H4OH, o-, m-, p-MeC6H4OH, etc.) in MeCN gave the corresponding 3-aryloxy-6-fluoropyridazines in 64-89% yields. 3,6-Diphenoxy- and 3-(dimethylamino)-6-fluoropyridazines were also prepared, and treatment of I with PhOK in MeCN gave 3-chloro-6-phenoxypyridazine. The 3-aryloxy-6-fluoropyridazines showed herbicidal activities (barnyard grass). In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Related Products of 33097-39-1).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Related Products of 33097-39-1
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem