Studies on pyridazine derivatives. IX. Note on the ethoxycarbonylation of pyridazinylhydrazones was written by Matyus, P.;Szilagyi, G.;Kasztreiner, E.;Soti, M.;Sohar, P.. And the article was included in Acta Chimica Academiae Scientiarum Hungaricae in 1982.Application of 33050-32-7 This article mentions the following:
Triazolopyridazine derivative I and pyridazine derivative II were prepared, under different conditions, from the pyridazinylhydrazone III and EtO2COCO2Et. The reaction of III with EtO2COCO2Et at -10° gave I. A mixture of III and EtO2COCO2Et in CH2Cl2 was refluxed to give II. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Application of 33050-32-7).
6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Application of 33050-32-7
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem