Synthesis of 6H-1,2,4-triazino-1,2,4-triazolopyridazines. Studies in the field of pyridazine compounds. 22 was written by Kosary, Judit;Jerkovich, Gyula;Polos, Katalin;Kasztreiner, Endre. And the article was included in Magyar Kemiai Folyoirat in 1986.HPLC of Formula: 33050-32-7 This article mentions the following:
The novel ring system 6H-1,2,4-triazino[4,3-b]-1,2,4-triazolo[3,4-f]pyridazine I (R = H, Ph) was prepared either by ring closure of triazolopyridazinylhydrazine derivatives II in polyphosphoric acid or of a hydrazine derived from pyridazino-1,2,4-triazine under the action of tri-Et orthoformate. The first representative of another new ring system 6H-1,2,4-triazino[4,3-b]-1,2,4-triazolo[3,4-f]pyridazine III was prepared by heating triazolopyridazinylhydrazone derivative IV in polyphosphoric acid. I (R = H) and III showed a pos. inotropic effect. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7HPLC of Formula: 33050-32-7).
6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.HPLC of Formula: 33050-32-7
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem