With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51149-08-7,3,6-Dichloropyridazine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
51149-08-7, 2,5-Dichloro-pyridizine-3-carboxylate (0.40 g, 2.07 mmol) in toluene (8 ML) was reacted with triethylamine (0.72 ML, 5.20 mmol) and benzyl amine (0.23 ML, 2.07 mmol) at 90 C. for 8 hours.The solution was partitioned between water and ethyl acetate.The organic layer was dried over sodium sulfate, filtered, and concentrated to yield the title compound (0.257 g, 47%). MS (DCI/NH3) m/z 264 (M+H+)+.
The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pemela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/87577; (2004); A1;,
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