Varney, Michael D. published the artcileSynthesis and Biological Evaluation of Novel 2,6-Diaminobenz[cd]indole Inhibitors of Thymidylate Synthase Using the Protein Structure as a Guide, Recommanded Product: Pyridazine-4-carbaldehyde, the publication is Journal of Medicinal Chemistry (1995), 38(11), 1892-903, database is CAplus and MEDLINE.
The design, synthesis, and biochem. and biol. evaluations of a novel series of 2,6-diaminobenz[cd]indoles I (R1, R2 = H, Me; X = H; N = methine, nitrogen) of were prepared as inhibitors of human thymidylate synthase (TS) are described. The compounds are characterized by having either a pyridine or pyridazine ring in place of the (phenylsulfonyl)morpholinyl group of the known inhibitor N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate. Active compounds from this series showed human TS inhibition constants below the 10 nM level and were potent, selective submicromolar antitumor agents in cell culture. The compounds were synthesized by reductive alkylation of a substituted 6-aminobenz[cd]indole or reductive cyclization of a substituted 1-cyano-8-nitronaphthalene.
Journal of Medicinal Chemistry published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C9H8O4, Recommanded Product: Pyridazine-4-carbaldehyde.
Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem