Crossland, Ingolf published the artcileAddition of Grignard reagents to pyridazines. X. 3-Chloro-6-dimethylaminopyridazine, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine, the main research area is pyridazines Grignard alkylation; Grignard alkylation pyridazines; alkylation Grignard pyridazines.
The reaction of 3-chloro-6-dimethylaminopyridazine with EtMgBr and PhMgBr gives 5-substituted-3-chloro-4,5-dihydro-6-dimethylaminopyridazines; the corresponding reactions with tert-BuMgBr afford 4-alkylated-4,5-dihydropyridazines. Iso-PrMgBr gives about equal amounts of the two isomers. The dihydropyridazines are identified by oxidation to the corresponding 4- or 5-substituted 3-chloro-6-dimethylaminopyridazines, which are subsequently dehalogenated and subjected to NMR anal. The results may be rationalized in terms of electronic and steric effects.
Acta Chemica Scandinavica (1947-1973) published new progress about Grignard reaction. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem