Albright, J. D. published the artcileSynthesis and anxiolytic activity of 6-(substituted-phenyl)-1,2,4-triazolo[4,3-b]pyridazines, Category: pyridazine, the main research area is triazolopyridazine phenyl; anxiolytic phenyltriazolopyridazine; antihypertensive phenyltriazolopyridazine; diazepam binding inhibition phenyltriazolopyridazine.
Fifty-six title compounds I (R = H, Me, Ph, etc.; R1 = H, F, Cl, NO2, etc.) were prepared in 5-92% yields starting from R1C6H4COCH2CH2CO2Et. Some I show activity in tests predictive of anxiolytic activity (protection against pentylenetetrazole-induced convulsions; thirsty rat conflict procedure). I also represent a new class of compounds which inhibit 3H-diazepam binding. Structure-activity correlations, as well as the ability of I to inhibit 3H-diazepam binding (in vitro) were discussed.
Journal of Medicinal Chemistry published new progress about Antihypertensives. 58059-33-9 belongs to class pyridazine, name is 3-Chloro-6-(3-nitrophenyl)pyridazine, and the molecular formula is C10H6ClN3O2, Category: pyridazine.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem