Pifferi, Giorgio published the artcileSynthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine, the main research area is antihypertensive hydrazinopyridazine derivative; pyridazine hydrazino derivative antihypertensive.
Of a series of 19 title compounds substituted in the 6 position with a primary or secondary amine or an alkoxy group, several were more active than hydralazine [86-54-4] in cats as hypotensive agents and as antihypertensive agents in renal hypertensive rats. I [56393-22-7] and II [56393-23-8], prepared from 3,6-dichloropyridazine [141-30-0] by displacement of 1 Cl with the appropriate amine, followed by reaction with hydrazine and benzaldehyde, followed by hydrolysis of the hydrazone, displayed high potency and low toxicity in the tests. I reduced peripheral resistance and increased aortic, femoral, and coronary blood flow in dogs. Structure-activity relations are discussed.
Journal of Medicinal Chemistry published new progress about Antihypertensives. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Safety of 6-Chloro-N,N-dimethylpyridazin-3-amine.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem