Di Mola, N. published the artcilePotential antihypertensives. Synthesis of 6-substituted-N-(4H-1,2,4-triazol-4-yl)-3-pyridazinamines and 3-substituted-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyridazines, SDS of cas: 17259-32-4, the main research area is pyridazinaminotriazole preparation antihypertensive; triazolylaminopyridazine preparation antihypertensive; antihypertensive dimethyltriazolylpyridazine.
A series of 6-substituted-N-(4H-1,2,4-triazol-4-yl)-3-pyridazinamines [I, R = H, Me; R1 = morpholino, piperidino, N(CH2CH2OMe)2] and 3-substituted-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyridazines (II, R2 = R1, OMe, OEt, 3-tert-butyl-2-phenyl-5-oxazolidinylmethoxy, OCH2CH(OH)CH2NHCMe3, NHNH2, NHN:CHPh, 2,5-dimethylpyrrolylamino, 2,5-diethylpyrrolylamino, NHNHCO2Et) were prepared and evaluated for their oral antihypertensive activity in spontaneously hypertensive rats. Only some II induced a moderate decrease in systolic blood pressure.
Farmaco, Edizione Scientifica published new progress about Antihypertensives. 17259-32-4 belongs to class pyridazine, name is 4-(6-Chloropyridazin-3-yl)morpholine, and the molecular formula is C8H10ClN3O, SDS of cas: 17259-32-4.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem