Ibrahim, Tamer H. published the artcileSynthesis of Some Novel 2,6-Disubstituted Pyridazin-3(2H)-one Derivatives as Analgesic, Anti-Inflammatory, and Non-Ulcerogenic Agents, Formula: C6H8ClN3, the main research area is alkyl phenoxypyridazinone preparation analgesic antiinflammatory ulcerogenic cyclooxygenase inhibitor SAR; benzyl aminopyridazinone preparation analgesic antiinflammatory ulcerogenic cyclooxygenase inhibitor SAR; aralkyl pyrazolylpyridazinone preparation analgesic antiinflammatory ulcerogenic cyclooxygenase inhibitor SAR; Analgesic activity; Anti-inflammatory; COX-1; COX-2; Pyridazinone.
Some novel 2,6-disubstituted pyridazine-3(2H)-one derivatives I [R1 = p-tolyl, benzyl, 2,6-di-MeC6H3, etc; R2 = Et, Ph, 4-Br-C6H4, phthalimido; X = N, O] and II [R3 = Ph, 4-Br-C6H4, phthalimido] were synthesized and evaluated for in-vitro cyclooxygenase-2 (COX-2) inhibitory efficacy. Compounds I [R1 = o-tolyl, R2 = phthalimido, X = O; R1 = o-tolyl, R2 = Et, X = O] and II [R3 = Ph] showed the most potent COX-2 inhibitory activity with IC50 values of 0.19, 0.11, and 0.24 μM, resp. The synthesized compounds with the highest COX-2 selectivity indexes were evaluated for their anti-inflammatory, analgesic, and ulcerogenic activities. Compounds I [R1 = o-tolyl, R2 = Et, X = O] and II [R3 = Ph] demonstrated the most potent and consistent anti-inflammatory activity over the synthesized compounds, which was significantly higher than that of celecoxib in the carrageenin rat paw edema model and with milder ulcer scoring than that of indomethacin in the ulcerogenicity screening.
Archiv der Pharmazie (Weinheim, Germany) published new progress about Analgesics. 7145-60-0 belongs to class pyridazine, name is 6-Chloro-N,N-dimethylpyridazin-3-amine, and the molecular formula is C6H8ClN3, Formula: C6H8ClN3.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem