With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35857-89-7,6-Chloropyridazine-3-carbonitrile,as a common compound, the synthetic route is as follows.
5-chloro -N2- (1,3- dimethyl -1H- pyrazol-4-yl) -N4- (3- ethyl-piperidin-4-yl) – pyrimidine-2,4-diamine ( 202.7mg, 0.58mmol) in EtOH (10mL) was added 6-chloro-pyridine-3-carbonitrile (162.3mg, 1.17mmol) and triethylamine (0.35mL, 2.5mmol) in solution. IncomeThe mixture was warmed to reflux and stirred overnight, then concentrated under reduced pressure. MeOH solution was purified by preparative thin layer chromatography, the residue of ammonia (3M in / DCM(V / v) = 1/20) to give the title compound as a white solid (91.9mg, 35.1% yield)., 35857-89-7
35857-89-7 6-Chloropyridazine-3-carbonitrile 13382871, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem