In 1977,Chemical & Pharmaceutical Bulletin included an article by Yanai, Mitsuji; Takeda, Shigeko; Mitsuoka, Tamao. Category: pyridazine. The article was titled 《Studies on heterocyclic compounds. XX. The reaction of 4-cyano-3,6-dichloropyridazine with amines》. The information in the text is summarized as follows:
4-Cyano-3,6-dichloropyridazine (I) was treated with primary amines in MeOH under mild conditions (stirring at 0-5°) to give the corresponding 5-amino derivatives II (R = NHCH2CH2OH, NH2, PhCH2NH, NHMe, etc.) resulting from nuclear amination. When I was treated with secondary amines, the corresponding 3- or 6-amino derivatives were obtained.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Category: pyridazine) was used in this study.
3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Category: pyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem