Luraschi, Elena; Arena, Francesca; Sacchi, Antonia; Laneri, Sonia; Abignente, Enrico; Avallone, Lucia; D’amico, Michele; Berrino, Libero; Rossi, Francesco published the artcile< Research on heterocyclic compounds. XXXVIII. Synthesis and pharmacological activity of imidazo[1,2-b]pyridazine-2-carboxylic derivatives>, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate, the main research area is imidazopyridinecarboxylic acid derivative preparation antiinflammatory structure.
A series of imidazo[1,2-b]pyridazine-2-carboxylic acids, esters and amides was synthesized and tested for antiinflammatory, analgesic and ulcerogenic activities. The Et esters were prepared by cyclocondensation of some 3-aminopyridazines with Et bromopyruvate, followed by hydrolysis or ammonolysis to obtain the corresponding acids and amides. The inhibitory activity on the carrageenan-induced edema in the rat paw and on writhes induced by acetic acid in mice was evaluated, as well as the ulcerogenic action on the rat gastric mucosa. The pharmacol. activity was discussed in terms of structure-activity relationships. In particular, the analgesic activity shown by these carboxylic derivatives was compared with that found in other series of imidazo[1,2-b]pyridazine analogs previously examined
Farmaco published new progress about Analgesics. 64067-99-8 belongs to class pyridazine, and the molecular formula is C9H8ClN3O2, Recommanded Product: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem