Haider, Norbert; Hochholdinger, Iris; Matyus, Peter; Wobus, Andrea published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Synthesis of ortho-functionalized 4-aminomethylpyridazines as substrate-like semicarbazide-sensitive amine oxidase inhibitors》.COA of Formula: C5H2ClN3 The author mentioned the following in the article:
A series of 4-aminomethylpyridazines and -pyridazin-3(2H)-ones (diaza-benzylamines), bearing alkylamino side chains in ortho position relative to the CH2NH2 unit, was synthesized by catalytic hydrogenation of nitriles in strongly acidic medium. N-Benzyl protecting groups either at the pyridazinone ring nitrogen or at an exocyclic nitrogen were selectively removed hydrogenolytically or by treatment with a Lewis acid. The new compounds were tested in vitro for semicarbazide-sensitive amine oxidase (SSAO) inhibitory activity and 4-(aminomethyl)-N,N’-diethylpyridazine-3,5-diamine was found to be the most active representative.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3COA of Formula: C5H2ClN3) was used in this study.
3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.COA of Formula: C5H2ClN3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem