In 1971,Chemical & Pharmaceutical Bulletin included an article by Yanai, Mitsuji; Kinoshita, Toshio; Watanabe, Hiroshi; Iwasaki, Susumu. Name: 3,6-Dichloropyridazine-4-carboxamide. The article was titled 《Pyridazine derivatives. XIV. Synthesis and reaction of pyrimido-[4,5-c]pyridazines》. The information in the text is summarized as follows:
New pyrimido[4,5-c]pyridazines were prepared by cyclization of 3-amino-4-carbamoylpyridazines (I, R=Cl, R1=NH2; R=NH2, R1=Cl) and 3-chloro-4-(ethoxycarbonyl)pyridazine. When 3-chloro-5-hydroxypyrimido[4,5-c]pyridazine was treated with POCl3 and N,N-dimethylaniline, 1,4-dihydro-3,5-dichloro-4-[4-(N,N-dimethylamino)phenyl]pyrimido[4,5-c]pyridazine (II) was obtained; the structure was established by NMR spectra of the dechlorination and hydrolysis products. Amination of II afforded 3-chloro-5-amino compounds. In the experiment, the researchers used 3,6-Dichloropyridazine-4-carboxamide(cas: 27427-66-3Name: 3,6-Dichloropyridazine-4-carboxamide)
3,6-Dichloropyridazine-4-carboxamide(cas: 27427-66-3) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: 3,6-Dichloropyridazine-4-carboxamide
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem