Kim, Chang Kon; Lee, Bon Su; Lee, Ikchoon published an article on February 20 ,1992. The article was titled 《Determination of reactivity by MO theory. 78. Theoretical studies on the gas-phase pyrolysis of 2-alkoxypyrimidines, 2-alkoxypyrazines, 4-ethoxypyrimidine and 3-ethoxypyridazine》, and you may find the article in Bulletin of the Korean Chemical Society.Synthetic Route of C6H8N2O The information in the text is summarized as follows:
The gas-phase pyrolysis reactions of 2-alkoxypyrimidines (II), 2-alkoxypyrazines (III), 4-ethoxypyrimidine (IV) and 3-ethoxypyridazine (V) are investigated theor. using the AM1 MO method. These compounds pyrolyze in a concerted retro-ene process with a six-membered cyclic transition state (TS). The relative order of reactivity is (IV) > (II) > (III) > (V), which can be rationalized by the two effects arising from electron-withdrawing power of the aza-substituent: (i) electron withdrawal from the C-O bond accelerates the rate and (ii) electron withdrawal from the N1-atom, that is participating in the six-membered TS, deactivates the reaction. The exptl. result of the greatest reactivity for pyridazine, (V), cannot be explained with the AM1 results. The reactivity increase accompanied by successive methylation of the ethoxy group, ethoxy < iso-propoxy > tert-butoxy, is due to a release of steric crowding in the activation process. In the part of experimental materials, we found many familiar compounds, such as 3-Ethoxypyridazine(cas: 62567-44-6Synthetic Route of C6H8N2O)
3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C6H8N2O
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem