HPLC of Formula: 65202-52-0《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in 2016. The authors were Ohno, Hiroaki;Minamiguchi, Daiki;Nakamura, Shinya;Shu, Keito;Okazaki, Shiho;Honda, Maho;Misu, Ryosuke;Moriwaki, Hirotomo;Nakanishi, Shinsuke;Oishi, Shinya;Kinoshita, Takayoshi;Nakanishi, Isao;Fujii, Nobutaka, and the article was included in《Bioorganic & Medicinal Chemistry》. The author mentioned the following in the article:
Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.017 μM; IC50 (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.016 μM; IC50 (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC50 (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound To complete the study, the researchers used Methyl 6-bromopyridazine-3-carboxylate (cas: 65202-52-0) .
The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate.HPLC of Formula: 65202-52-0 It is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem