The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methoxy-1H-indole-2-carbaldehyde(SMILESS: O=CC(N1)=CC2=C1C=CC(OC)=C2,cas:21778-81-4) is researched.Product Details of 21778-81-4. The article 《Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:21778-81-4).
The aromatic nitrogen atoms of heteroarylaldehydes were activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products I [R1 = H, 8′-Br, 7′-Cl, etc.; R2 = H, 4-Br, 5-Cl, etc.; R3 = Me, Bn, Trt], II [R1 = H, 8-Br, 7-F, etc.; R2 = H, 3-Me, 4-Cl, etc.; R3 = Me, Et, Ph, Bn, CHPh2] and III [R1 = H, 6;t-Bu, 7’Cl, etc.; R2 = H, 4-Cl, 5-Me, etc.] were afforded in good to excellent yields and optical purities. Reaction involved the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibited excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichems. for plant protection.
After consulting a lot of data, we found that this compound(21778-81-4)COA of Formula: C10H9NO2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem