In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of 4-Amino and 4-Hydroxy-1-aroylindoles as Potent Tubulin Polymerization Inhibitors, published in 2008-07-24, which mentions a compound: 21778-81-4, mainly applied to indole trimethoxybenzoyl chloride aroylation; trimethoxybenzoic anhydride indole acylation; indoline trimethoxybenzoyl chloride aroylation; tetrahydroquinoline trimethoxybenzoyl chloride acylation; aroylindole derivative preparation antitubulin anticancer activity; aroylindoline derivative preparation antitubulin anticancer activity; aroyltetrahydroquinoline derivative preparation antitubulin anticancer activity, Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.
1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives, e.g., I and II, were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles I and II, with IC50 of 0.9 and 0.6 μM, resp., exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC50 of 0.3-5.4 nM in a set of human cancer cell lines.
After consulting a lot of data, we found that this compound(21778-81-4)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem