The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis, the main research direction is aryl benzothiazolamine preparation trypanosomicide human African trypanosomiasis treatment.Related Products of 136725-55-8.
A previous publication from this lab explored the antitrypanosomal activities of novel derivatives of 2-(2-benzamido)ethyl-4-phenylthiazole, which had been identified as a hit against Trypanosoma brucei, the causative agent of human African trypanosomiasis. While a number of these compounds, particularly the urea analogs, were quite potent, these mols. as a whole exhibited poor metabolic stability. The present work describes the synthesis of 65 new analogs arising from medicinal chem. optimization at different sites on the mol. The most promising compounds were the urea derivatives of 2-aryl-benzothiazol-5-amines. One such analog, (S)-2-(3,4-difluorophenyl)-5-(3-fluoro-N-pyrrolidylamido)benzothiazole (I) was chosen for in vivo efficacy studies based upon in vitro activity, metabolic stability, and brain penetration. This compound attained 5/5 cures in murine models of both early and late stage human African trypanosomiasis, representing a new lead for the development of drugs to combat this neglected disease.
Compounds in my other articles are similar to this one((R)-(-)-3-Fluoropyrrolidine Hydrochloride)Related Products of 136725-55-8, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem