So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Lei; Zheng, Mingyue; Zhao, Fei; Zhai, Yun; Liu, Hong researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Name: 5-Methoxy-1H-indole-2-carbaldehyde.They published the article 《Rapid Generation of Privileged Substructure-Based Compound Libraries with Structural Diversity and Drug-Likeness》 about this compound( cas:21778-81-4 ) in ACS Combinatorial Science. Keywords: indolecarboxaldehyde amine carboxylic acid isonitrile Ugi intramol arylation cyclization; heterocyclic compound library preparation structural diversity drug likeness. We’ll tell you more about this compound (cas:21778-81-4).
A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic anal. confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.
As far as I know, this compound(21778-81-4)Name: 5-Methoxy-1H-indole-2-carbaldehyde can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem