In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery, published in 2020-11-30, which mentions a compound: 17739-45-6, mainly applied to Escherichia macrophage lipopolysaccharide POPC cardiolipin antimicrobial; Antibiotic resistance; Biomimetic membranes; Giant unilamellar vesicles; Nanomedicine; Transcription factor decoys, Name: 2-(2-Bromoethoxy)tetrahydro-2H-pyran.
The development of new therapeutic strategies against multidrug resistant Gram-neg. bacteria is a major challenge for pharmaceutical research. Here, we explore the multifunctional therapeutic potential of nanostructured self-assemblies from a cationic bolaamphiphile, which target bacterial lipopolysaccharides (LPSs) and associates with an anti-bacterial nucleic acid to form nanoplexes with therapeutic efficacy against Gram-neg. bacteria. To understand the mechanistic details of these multifunctional antimicrobial-anti-inflammatory properties, we performed a fundamental study, comparing the interaction of these nanostructured therapeutics with synthetic biomimetic bacterial membranes and live bacterial cells. Combining a wide range of exptl. techniques (Confocal Microscopy, Fluorescence Correlation Spectroscopy, Microfluidics, NMR, LPS binding assays), we demonstrate that the LPS targeting capacity of the bolaamphiphile self-assemblies, comparable to that exerted by Polymixin B, is a key feature of these nanoplexes and one that permits entry of therapeutic nucleic acids in Gram-neg. bacteria. These findings enable a new approach to the design of efficient multifunctional therapeutics with combined antimicrobial and anti-inflammatory effects and have therefore the potential to broadly impact fundamental and applied research on self-assembled nano-sized antibacterials for antibiotic resistant infections.
This literature about this compound(17739-45-6)Name: 2-(2-Bromoethoxy)tetrahydro-2H-pyranhas given us a lot of inspiration, and I hope that the research on this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem