With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141-30-0,3,6-Dichloropyridazine,as a common compound, the synthetic route is as follows.
To a 1000 mL single-necked round bottom flask was added 3,6-dichloropyridazine (29.80 g, 200 mmol), hydrazine hydrate (15.00 g, 300 mmol), DMF and acetonitrile (280 ml of DMF). The reaction mixture was stirred at 90 C for 10 hours. TLC and GC were determined to complete the reaction. After the reaction, the solvent was removed by steaming, get the crude product, the pure product was isolated by silica gel column chromatography 3-chloro-6-hydrazinopyridazine, after drying, the calculated yield was 83.65%. Purity 98.69% (HPLC)., 141-30-0
The synthetic route of 141-30-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shandong Youbang Biochemical Technology Co., Ltd.; Geng Xuanping; Lai Chao; Lai Ziteng; Lai Xinsheng; (4 pag.)CN106632069; (2017); A;,
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