The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.Name: 5-Methoxy-1H-indole-2-carbaldehyde.Gao, Yuning; Xu, Qin; Shi, Min published the article 《Enantioselective Synthesis of Polycyclic Indole Derivatives Based on aza-Morita-Baylis-Hillman Reaction》 about this compound( cas:21778-81-4 ) in ACS Catalysis. Keywords: imine acrylate chiral phosphine enantioselective Morita Baylis Hillman RCM; polycyclic indole derivative stereoselective preparation. Let’s learn more about this compound (cas:21778-81-4).
A chiral phosphine-catalyzed asym. aza-Morita-Baylis-Hillman reaction between indole-derived sulfonyl imines and bis(3-chlorophenyl)methyl acrylate has been developed, giving the desired adducts in good yields and enantiomeric excess values along with the further transformations to polycyclic indoles such as dihydropyrido[1,2-a]indole and dihydropyrazino[1,2-a]indole skeleton.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem