So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xie, Chao-Chao; Tan, Rui; Liu, Yan-Kai researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Category: pyridazine.They published the article 《Asymmetric construction of polycyclic indole derivatives with different ring connectivities by an organocatalysis triggered two-step sequence》 about this compound( cas:21778-81-4 ) in Organic Chemistry Frontiers. Keywords: polycyclic indole preparation regioselective stereoselective; hemiacetal indole nitroolefin tandem Michael addition alkylation organocatalysis. We’ll tell you more about this compound (cas:21778-81-4).
An organocatalysis triggered highly regio- and stereoselective two-step sequence between hemiacetals and indole-containing nitroolefins was developed. The key to the success of this sequence was the intramol. oxocarbenium ion induced collective alkylation at the C3, C2, or N1-position of the indole moiety, resp., providing biol. important polycyclic indole derivatives with different ring connectivities. An unexpected epimerization was observed during the C3-alkylation process, which generated products with different relative configurations compared with the C2- and N1-alkylation products.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem