1121-79-5, 3-Chloro-6-methylpyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 139; N-[9-(3-Fluoro-benzyl)-6-(6-methyl-pyridazin-3-yl)-2,3,4,9-tetrahydro-lH- carbazol-3-yl]-isobutyramideDissolve N-[9-(3-flourobenzyl)-6-(4,4,5,5-tetramethyl[l ,3,2]dioxaborolan-2- yl)-2,3,4,9-tetrahydro-lH-carbazol-3-yl]isobutyramide (Preparation 23) (150 mg, 0.31 mmol) and 3-chloro-6-methylpyridazine (39 mg, 0.31 mmol) in dioxane (2.5 mL) and 2M Na2Ctheta3 (388 muL). Sparge the solution with nitrogen for 5 min, add dichlorobis(triphenylphosphine)palladium (S) (11 mg, 0.016 mmol) and seal the reaction vessel. Heat to 140 0C in a microwave reactor for 30 min, then dilute with water (20 mL). Extract into EtOAc (3 x 25 mL), dry organics (MgSO4), filter, and concentrate in-vacuo to give the crude product (179 mg) as a brown solid. Purify the crude product on silica gel (12 g), eluting with 25-70% (4% (2M NH3/Me0H)/CH2Cl2)/hexanes to afford 35 mg (25%) of the title compound as a white solid. MS (ES): m/z 457 (M+l), 455 (M-I); HPLC (Method B) Rt = 3.37 min (100%).
1121-79-5, As the paragraph descriping shows that 1121-79-5 is playing an increasingly important role.
Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem