With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.372118-01-9,Methyl 4,6-dichloropyridazine-3-carboxylate,as a common compound, the synthetic route is as follows.
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (600 mg, 2.90 mmol),2,6-difluorophenylboronic acid (1.37 g, 8.70 mmol),Diisopropylethylamine (3g, 23.2mmol), [1,1?-bis (diphenylphosphine) ferrocene] palladium dichloromethane complex (118mg, 0.145mmol)Mixed with 1,4-dioxane (15mL),After deoxygenation, it was heated to 110 C in a microwave reactor under a nitrogen atmosphere and stirred for 1 hour.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 17/3),The target product 4-chloro-6- (2,6-difluorophenyl) pyridazine-3-carboxylic acid methyl ester 67a (223 mg, white solid) was obtained in a yield of 27%., 372118-01-9
The synthetic route of 372118-01-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
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