With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50681-25-9,4-Pyridazinecarboxylic Acid,as a common compound, the synthetic route is as follows.,50681-25-9
Preparation 3: methyl 4-pyridazinecarboxylic acid; To a solution of 4-pyridazinecarboxylic acid (490 mg, 3.9 mmol) in MeOH/DCM (20/10 ml) was added at 0 0C trimethylsilildiazomethane (25.5 mmol). The solution was warm at r.t. and stirred overnight. Volatiles were evaporated in vacuo, the crude dissolved in DCM, washed with NaHCO3 satured and dried over Na2SO4. After filtration and concentration to dryness in vacuo, the crude was purified by column chromatography (DCM:MeOH=98 to2) to give 400 mg of the title compound.NMR (1H, CDCI3): delta 9.65 (s, 1 H)1 9.4 (d, 1 H), 7.98 (d, 1 H)1 4.0 (s, 3H). MS (mlz): 139[MH]+.
50681-25-9 4-Pyridazinecarboxylic Acid 2761046, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/108701; (2006); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem