The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.Category: pyridazine.Das, Tapas; Kayet, Anirban; Mishra, Ruchika; Singh, Vinod K. published the article 《Highly fluorescent 1,2-dihydropyrimido[1,6-α]indoles: an efficient metal-free synthesis and photophysical study》 about this compound( cas:21778-81-4 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: dihydropyrimidoindole preparation; indole carboxaldehyde ethyl arylideneglycinate aldol Mannich reaction. Let’s learn more about this compound (cas:21778-81-4).
A metal-free route to highly fluorescent 1,2-dihydropyrimido[1,6-α]indole derivatives I (R = H, OCH3, CH3, Br; Ar = C6H5, naphth-1-yl, furan-2-yl, etc.) has been developed via base catalyzed aldol followed by the Mannich reaction of indole-2-carboxaldehydes II with Et N-arylideneglycinates ArHC=NCH2COOEt at room temperature This transformation consists of the sequential formation of two new bonds to afford highly functionalized pyrimidoindole derivatives under mild reaction conditions.. Photophys. properties of the products have also been reported.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem