Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 21778-81-4, is researched, Molecular C10H9NO2, about Asymmetric Sequential Corey-Chaykovsky Cyclopropanation/Cloke-Wilson Rearrangement for the Synthesis of 2,3-Dihydrofurans, the main research direction is alkynyl isothiocineole indolyl acrylonitrile diastereoselective enantioselective Cloke Wilson rearrangement; progaryl sulfonium salt indolyl acrylonitrile diastereoselective Cloke Wilson rearrangement; indolyl furan preparation Corey Chaykovsky cyclopropanation.Safety of 5-Methoxy-1H-indole-2-carbaldehyde.
The first sequential Corey-Chaykovsky cyclopropanation/Cloke-Wilson rearrangement between propargyl sulfonium salts and acrylonitrile derivatives was developed, affording the tetra-substituted 2,3-dihydrofurans in generally excellent yields (57-98%) with good diastereoselectivities (7:1-18:1). In addition, chiral propargyl sulfonium salt is also suitable for this strategy, giving the optically active 2,3-dihydrofurans with good enantioselectivities. This reaction sequence was designed upon in situ generated 10π-conjugated structures from the dearomatization of indole fragments and subsequent intramol. 1,6-addition
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem