With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19064-67-6,6-Chloro-3-hydroxypyridazine,as a common compound, the synthetic route is as follows.
Compound 2 (2 mmol),4-methoxycarbonylbenzeneboronic acid (2 mmol),Copper acetate (0.4 mmol),Pyridine (0.4 mmol) in the reaction flask,Add 15 mL of DMF and dissolve at room temperature with stirring.Open reaction for about 4 hours,The reaction was complete by TLC.Add appropriate amount of ethyl acetate for extraction.Washed with saturated saline,The organic phase is concentrated,Separation and purification by silica gel column chromatography (ethyl acetate /Petroleum ether = 1/3),Obtained 2.1 g of white solid compound 25,The yield was 80%.
19064-67-6, The synthetic route of 19064-67-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Geng Meiyu; Duan Wenwen; Ding Jian; Wan Penghui; Shen Aijun; Lu Dong; Liu Hongchun; Wei Aihuan; Zhang Minmin; Zeng Limin; Cao Jingchen; (57 pag.)CN109280032; (2019); A;,
Pyridazine – Wikipedia
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