In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists, published in 2014-08-01, which mentions a compound: 21778-81-4, mainly applied to stereoselective Wittig indolecarboxaldehyde oxo ETE receptor antagonist preparation; base dependent Wittig stereochem oxo ETE receptor antagonist preparation; 5-Oxo-ETE; Antagonist; Indolecarboxaldehyde; KHMDS; LiHMDS; Wittig reaction, Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.
5-Oxo-ETE is the most potent eosinophil chemoattractant among lipid mediators. We have developed two 5-oxo-ETE receptor antagonists. In the course of the work, we have developed a procedure to selectively introduce a cis and trans double bond in an alkyl side chain. Reacting indolecarboxaldehydes with alkyl ylides using the Li base affords the trans olefins, whereas using the K base yields the cis olefins.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Methoxy-1H-indole-2-carbaldehyde)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde, illustrating the importance and wide applicability of this compound(21778-81-4).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem