372118-01-9, Methyl 4,6-dichloropyridazine-3-carboxylate is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (1.22 g, 5.95 mmol),4- (3-methoxyoxetane-3-yl) aniline 69e (760mg, 4.25mmol),Diisopropylethylamine (1.65 g, 12.75 mmol) and acetonitrile (15 mL) were mixed, heated to 90 C. in a microwave reactor, and stirred for 3 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 1/2),The target product 6-chloro-4-((4- (3-methoxyoxetan-3-yl) phenyl) amino) pyridazine-3-carboxylic acid methyl ester 69f (850 mg, yellow solid) was obtained. yield: 57%., 372118-01-9
372118-01-9 Methyl 4,6-dichloropyridazine-3-carboxylate 17848322, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem