Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 5-(hydroxymethyl)picolinate, is researched, Molecular C8H9NO3, CAS is 39977-42-9, about Simultaneous dehalogenation and hydrogenation reduction of halogen-heteroaromatic aldehydes.Reference of Methyl 5-(hydroxymethyl)picolinate.
Treatment of halo-heteroaromatic aldehydes with a catalytic amount of PdCl2 under atm. pressure of H2 in base medium (NaOAc) leads to the corresponding dehalogenated primary alcs. The reaction system was especially effective for heteroaromatic compounds bearing aldehyde groups and halides (Br or Cl).
There is still a lot of research devoted to this compound(SMILES：O=C(OC)C1=NC=C(CO)C=C1)Reference of Methyl 5-(hydroxymethyl)picolinate, and with the development of science, more effects of this compound(39977-42-9) can be discovered.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem