The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.HPLC of Formula: 21778-81-4.Zhang, Lei; Zhao, Fei; Zheng, Mingyue; Zhai, Yun; Wang, Jiang; Liu, Hong published the article 《Selective Synthesis of 5,6-Dihydroindolo-[1,2-a]quinoxalines and 6,7-Dihydroindolo-[2,3-c]quinolines by Orthogonal Copper and Palladium Catalysis》 about this compound( cas:21778-81-4 ) in European Journal of Organic Chemistry. Keywords: dihydroindoloquinoxaline dihydroindoloquinoline preparation copper palladium catalyst; Ugi four component reaction. Let’s learn more about this compound (cas:21778-81-4).
In combination with the Ugi four-component reaction, two important indole-fused heterocycles were prepared in two steps from readily accessible starting materials. From the same set of Ugi adducts 5, 5,6-dihydroindolo[1,2-a]quinoxalines were rapidly generated in excellent yields by a copper-catalyzed N-H arylation pathway, whereas 6,7-dihydroindolo[2,3-c]quinolones were obtained by palladium-catalyzed C-H arylations in good yields without the protection of the indole N1 moiety. Microwave heating was used to accelerate these intramol. C-N and C-C bond-forming reactions performed under controlled reaction conditions.
There is still a lot of research devoted to this compound(SMILES：O=CC(N1)=CC2=C1C=CC(OC)=C2)HPLC of Formula: 21778-81-4, and with the development of science, more effects of this compound(21778-81-4) can be discovered.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem