So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Hailong; Zhang, Lei; Zhao, Fei; Liu, Hong researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).Safety of 5-Methoxy-1H-indole-2-carbaldehyde.They published the article 《Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[4,3-b|indoles Using Copper Catalysis》 about this compound( cas:21778-81-4 ) in European Journal of Organic Chemistry. Keywords: dihydropyrazoloindole preparation; formylindole hydrazine cyclization microwave irradiation copper catalyst. We’ll tell you more about this compound (cas:21778-81-4).
A convenient three-step one-pot copper-catalyzed method has been developed for the preparation of pyrazolo[4,3-b]indoles, new indole-based compounds with potential biol. activity. Treatment of various hydrazines, including alkyl hydrazines, with indole-2-carbaldehydes generated the corresponding products in moderate to good yields without protection of the indole N-1 moiety. In addition, LiOH was used as a base in the copper-catalyzed coupling reaction. Microwave heating was used to accelerate the iodination of indoles and the C-N bond formation.
If you want to learn more about this compound(5-Methoxy-1H-indole-2-carbaldehyde)Safety of 5-Methoxy-1H-indole-2-carbaldehyde, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(21778-81-4).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem