Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Nature Catalysis called Gold-catalysed asymmetric net addition of unactivated propargylic C-H bonds to tethered aldehydes, Author is Li, Ting; Cheng, Xinpeng; Qian, Pengcheng; Zhang, Liming, which mentions a compound: 17739-45-6, SMILESS is BrCCOC1CCCCO1, Molecular C7H13BrO2, COA of Formula: C7H13BrO2.
The asym. one-step net addition of unactivated propargylic C-H bonds to aldehydes such as 7-(dimethyl(phenyl)silyl)hept-6-ynal, 4-(benzyloxy)-7-(tert-butyldimethylsilyl)hept-6-ynal, 7-(tert-Butyldimethylsilyl)-2-phenylhept-6-ynal, etc. leads to an atom-economic construction of versatile chiral homopropargylic alcs. e.g., I, but has not yet been realized. Here, implementation in an intramol. manner under mild reaction conditions have been showed. This chem.-via cooperative gold catalysis enabled by chiral bifunctional phosphine ligands (1R/1S)-II (R = Me, Cy; R1 = H, Me)-achieves asym. catalytic deprotonation of propargylic C-H (pKa > 30) by a tertiary amine group (pKa ≈ 10) of the ligand in the presence of much more acidic aldehydic α-hydrogens (pKa ≈ 17). The reaction exhibits a broad scope and readily accommodates various functional groups. The cyclopentane/cyclohexane-fused homopropargylic alc. products e.g., III are formed with excellent enantiomeric excesses and high trans-selectivities with or without a preexisting substrate chiral center. D. functional theory studies of the reaction support the conceived reaction mechanism and the calculated energetics corroborate the observed stereoselectivity and confirm addnl. metal-ligand cooperation.
If you want to learn more about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)COA of Formula: C7H13BrO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17739-45-6).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem