So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lena, Gersande; Trapani, Joseph A.; Sutton, Vivien R.; Ciccone, Annette; Browne, Kylie A.; Smyth, Mark J.; Denny, William A.; Spicer, Julie A. researched the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ).HPLC of Formula: 21778-81-4.They published the article 《Dihydrofuro[3,4-c]pyridinones as Inhibitors of the Cytolytic Effects of the Pore-Forming Glycoprotein Perforin》 about this compound( cas:21778-81-4 ) in Journal of Medicinal Chemistry. Keywords: furopyridinone dihydro arylmethylidene preparation inhibitor cytolytic effect glycoprotein perforin; pyrrolopyridinone arylmethylidene heteroarylmethylidene preparation inhibitor cytolytic effect glycoprotein perforin. We’ll tell you more about this compound (cas:21778-81-4).
Dihydrofuro[3,4-c]pyridinones are the first class of small mols. reported to inhibit the cytolytic effects of the lymphocyte toxin perforin. A lead structure was identified from a high throughput screen, and a series of analogs I (X = O, S; Y = O, NH; R = Ph, 4-FC6H4, 2-furyl, 5-methyl-2-thienyl, 3-thienyl, 2-benzofuryl, 3-benzothienyl, 3-indolyl, etc.) were designed and prepared to explore structure-activity relationships around the core bicyclic ring and pendant aryl(heteroaryl) ring. This resulted in the identification of a submicromolar inhibitor of the perforin-induced lysis of Jurkat T-lymphoma cells.
Here is a brief introduction to this compound(21778-81-4)HPLC of Formula: 21778-81-4, if you want to know about other compounds related to this compound(21778-81-4), you can read my other articles.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem