Continuously updated synthesis method about 136725-55-8

Here is a brief introduction to this compound(136725-55-8)HPLC of Formula: 136725-55-8, if you want to know about other compounds related to this compound(136725-55-8), you can read my other articles.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Varghese, Swapna; Rahmani, Raphael; Russell, Stephanie; Deora, Girdhar Singh; Ferrins, Lori; Toynton, Arthur; Jones, Amy; Sykes, Melissa; Kessler, Albane; Eufrasio, Amanda; Cordeiro, Artur Torres; Sherman, Julian; Rodriguez, Ana; Avery, Vicky M.; Piggott, Matthew; Baell, Jonathan B. researched the compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride( cas:136725-55-8 ).HPLC of Formula: 136725-55-8.They published the article 《Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi》 about this compound( cas:136725-55-8 ) in ACS Medicinal Chemistry Letters. Keywords: ethylurea pyrazole derivative preparation Trypanosoma brucei cruzi Chagas. We’ll tell you more about this compound (cas:136725-55-8).

Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, resp. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfactory, frequently associated with intolerable side-effects, and generally inadequate in treating all stages of disease. In this paper, we report the discovery of N-ethylurea pyrazoles that potently and selectively inhibit the viability of T. brucei and T. cruzi. Sharp and logical SAR led to the identification of 54 as the best compound, with an in vitro IC50 of 9 nM and 16 nM against T. b. brucei and T. cruzi, resp. Compound 54 demonstrates favorable physicochem. properties and was efficacious in a murine model of Chagas disease, leading to undetectable parasitemia within 6 days when CYP metabolism was inhibited.

Here is a brief introduction to this compound(136725-55-8)HPLC of Formula: 136725-55-8, if you want to know about other compounds related to this compound(136725-55-8), you can read my other articles.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem