With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57041-95-9,6-Aminopyridazin-3(2H)-one,as a common compound, the synthetic route is as follows.
57041-95-9, A mixture of 6-aminopyridazin-3-ol (2 g, 18.00 mmol), NaOH (0.720 g, 18.00 mmol) and Mel (1.126 mL, 18.00 mmol) was stirred for 2.5 hr at 85 00 under Ar. The reaction mixture was concentrated. The crude material was purified by silica gel column chromatography (NH3 1% ICH2CI2/MeOH 4-7%) to afford the title product (538 mg, 4.30 mmol, 24 % yield) as a yellowsolid. tR: 0.25 mm (LC-MS 2); ESI-MS: 126 [M+H] (LC-MS 2); R = 0.36 (CH2CI2/MeOH 9:1).
The synthetic route of 57041-95-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOVARTIS AG; BLANK, Jutta; BORDAS, Vincent; COTESTA, Simona; GUAGNANO, Vito; RUEEGER, Heinrich; VAUPEL, Andrea; WO2014/191896; (2014); A1;,
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