51149-08-7, 3,6-Dichloropyridazine-4-carboxylic acid is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
51149-08-7, Preparation 36; 3,6-Dichloropyridazine-4-carboxyiic acid ((J?)-1 soprapyIpIperidm~3~ yhnethyl)amide To 3,6-dichloropyridazine-4-carboxylic acid (Ig, 5.2mmol) in DCE (20mL) at 0C was added oxalyl chloride (1.36mL, 15.6mmoi) and DMF (2 drops). After 0.5h the solvent was removed in vacuo. The residue in DCE (lOmL) was added to C-((i?)-l- isopropylpiperidin-3-yl)methylamine phthalazinedione salt (Preparation 5) (1.5g, 4.7inmol) and NEt3 (0.66mL, 4.7mmol) in DCE (lOmL). After 0,5h the mixture was filtered and the solvent removed from the filtrate in vacuo. The residue was added to an MP-TsOH column, washed with MeOH and then crude product eluted with 2M NH3 in MeOH and the solvent was removed in vacuo. The residue was purified on a Biotage Isoiera (KP:NH column, Hexane to 100% EtOAc) to give, after removal of the solvent in vacuo, the title compound: RT- 1.70min; m/z (ES+) = 331.0 [M + llf.
The synthetic route of 51149-08-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PROSIDION LIMITED; BLOXHAM, Jason; BRADLEY, Stuart Edward; SAMBROOK-SMITH, Colin Peter; SMYTH, Donald; KEILY, John; DAWSON, Graham John; RASAMISON, Chrystelle Marie; BELL, James Charles; WO2011/117254; (2011); A1;,
Pyridazine – Wikipedia
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