With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.65202-58-6,3-Bromo-6-methylpyridazine,as a common compound, the synthetic route is as follows.,65202-58-6
EXAMPLE 5 Following a procedure similar to that of Example 3, 81 millimoles of 6-methyl-3-bromopyridazine was combined with 16 mL DIPEA and 163 mmoles of 4-hydroxypiperidine and heated to 120 for 16 hours to obtain 6-methyl-3-(4-hydroxy-1-piperdinyl)pyridazine (Formula IV: Y=bond, R=CH3) in 24% yield. 6.8 Mmols of the latter and 7.4 mmoles of 2-methyl-5-(4-hydroxy-3,5-dimethyl phenyl)-2H-tetrazole (Formula III: R2 =R3 =R4 =CH3) were reacted with equimolar amounts of DEAD and TPP essentially as described above in Example 1c.
As the paragraph descriping shows that 65202-58-6 is playing an increasingly important role.
Reference：
Patent; Sterling Winthrop Inc.; US5242924; (1993); A;,
Pyridazine – Wikipedia
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