17973-86-3, 3,6-Dibromopyridazine is a pyridazine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 8: 4-(6-Bromo-3-pyridazinyl)morpholine. 3,6-Dibromopyridazine (1.34g, 5.63mmol) was dissolved in acetonitrile (8ml), to this mo?holine(0.74ml, 8.45mmol) and triethylamine (1.22ml, 8.45mmol) were added and the suspension was irradiated in the microwave to 1600C for 80 minutes. The sample was then extracted between water(100ml) and dichloromethane (100ml). The mixture was poured through a hydrophobic frit collecting the dichloromethane layer which was evaporated to as dry as possible. The sample was then purified by chromatography (4* 10g of silica) eluting with 10% ethyl acetate/ dichloromethane to obtain the title compound (1.23g)1H-NMR (CDCl3) ? 3.59-3.61 (4H, m), 3.82-3.85 (4H, m), 6.79 (IH, d, J= 10), 7.35 (IH, d, J =10).LC/MS m/z [MH+] 246 consistent with molecular formula C8H1081BrN3O, 17973-86-3
17973-86-3 3,6-Dibromopyridazine 248852, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2007/22937; (2007); A1;,
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