With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20744-39-2,Pyridazin-4-amine,as a common compound, the synthetic route is as follows.
Example 142-{[(4-Fluorophenyl)methyl]oxy}-4-(1 -methyl-1 H-pyrazol-4-yl)-5-(4-morpholinylmethyl)-To a solution of methyl 2-{[(4-fluorophenyl)methyl]oxy}-4-(1-methyl-1 H-pyrazol-4-yl)-5-(4- morpholinylmethyl)benzoate (may be prepared as described in Description 18; 144 mg, 0.33 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (23.54 mg, 0.98 mmol) and water (1 ml). The mixture was stirred at room temperature for 18 hours then neutralised with 2M hydrochloric acid (0.79 ml, 1.59 mmol). The solvent was removed in vacuo and the residue redissolved in N,N-dimethylformamide (4 ml). Diisopropylethylamine (0.11 m, 0.66 mmol), 4-pyridazinamine (40.5 mg, 0.43 mmol), 1-hydroxy-7-azabenzotriazole (53.5 mg, 0.39 mmol) and EDC (94 mg, 0.49 mmol) were added and the solution was stirred for 3 hours. The solvent was removed in vacuo and the residue purified by MDAP to yield the title compound as a white solid. 57 mg.MS (electrospray): m/z, [M+H]+ = 5031 H NMR (400 MHz, DMSO-d6); 2.34 – 2.46 (4 H, m), 3.43 – 3.49 (2 H, m), 3.59 (4 H, t, J=4.14 Hz), 3.92 (3 H, s), 5.30 (2 H, s), 7.21 (2 H, t, J=8.91 Hz), 7.33 (1 H, s), 7.60 (2 H, dd, J=8.66, 5.65 Hz), 7.70 (1 H, s), 7.87 (1 H, s), 7.99 (1 H, dd, J=5.77, 2.76 Hz), 8.14 (1 H, s), 9.05 (1 H, d, J=5.77 Hz), 9.16 (1 H, d, J=1.76 Hz), 10.61 (1 H, s).
20744-39-2, As the paragraph descriping shows that 20744-39-2 is playing an increasingly important role.
Reference£º
Patent; GLAXO GROUP LIMITED; ANDREOTTI, Daniele; DAI, Xuedong; EATHERTON, Andrew John; JANDU, Karamjit Singh; LIU, Qian; PHILPS, Oliver James; WO2012/28629; (2012); A1;,
Pyridazine – Wikipedia
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