With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-79-5,3-Chloro-6-methylpyridazine,as a common compound, the synthetic route is as follows.
3-Chloro-6-methylpyridazine (3.00 g, 23.3 mmol) was dissolved in concentrated sulfuric acid (23 mL), and potassium dichromate (8.24 g, 28.0 mmol) was added little by little under ice cooling. The mixture was stirred at room temperature for 1.5 hours, and the mixture was further stirred at 50C for 60 hours. The reaction mixture was slowly poured into ice water, and the mixture was extracted with diethyl ether (x 3). The organic layer was washed with saturated sodium chloride solution and dried with anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to give the title compound (1.27 g; yield, 34%) as a white solid. 1H NMR (CDCl3, 400 MHz): delta 7.80 (1H, d, J = 7.8 Hz), 8.32 (1H, d, J = 7.8 Hz). MS (ESI) m/z: 159 (M+H) +.
1121-79-5, 1121-79-5 3-Chloro-6-methylpyridazine 227254, apyridazine compound, is more and more widely used in various fields.
Reference£º
Patent; Daiichi Sankyo Company, Limited; EP2409977; (2012); A1;,
Pyridazine – Wikipedia
Pyridazine | C4H4N2 – PubChem