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Analogs of compound 1 with a variety of azacycles and heteroaryl groups were synthesized. These analogs exhibited K(i) values ranging from 0.15 to > 10,000 nM when tested in vitro for cholinergic channel receptor binding activity (displacement of [3H](-) cytisine from whole rat brain synaptic membranes).

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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2144 – PubChem