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(2S,3R)- and (2R,3R)-2,3-Diaminobutanoic acid (Dab) derivatives were efficiently synthesized from Cbz-(R)-alanine using the proline-catalyzed diastereoselective alpha-hydrazination reaction and the SmI2-promoted reductive cleavage of the N-N bond as the key steps.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 20375-65-9 is helpful to your research.Related Products of 20375-65-9
Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N2692 – PubChem