With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1632-76-4,3-Methylpyridazine,as a common compound, the synthetic route is as follows.
To a solution of 3-methylpyridazine (4.60 g, 48.9 mmol) in acetic acid (30.0 mL) was added H202 (29.4 g,259 mmol, 29.4 mL, 30percent (w/w) in water). The mixture was heated at 120 00 for 6 h. The mixture wasallowed to cool to rt and poured in aqueous saturated NaHCO3 (500 mL) and extracted with DCM (5x 50 mL). The combined organic layer was dried over Na2SO4 and concentrated in vacuo to afford 6-methyl- pyridazine 1-oxide (2.22 g, 20.2 mmol, 41percent). LCMS: cal for [M+H} = 111.05, fd 111.2. 1H NMR shows a 1:1 mixture of both possible N-oxides.
1632-76-4, The synthetic route of 1632-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GRUeNENTHAL GMBH; NARDI, Antonio; RATCLIFFE, Paul; CRAAN, Tobias; HERTRAMPF, Thorsten; LESCH, Bernhard; STEINHAGEN, Henning; (70 pag.)WO2015/161924; (2015); A1;,
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