Quality Control of 3-Chloropyridazine, In chemical reaction engineering, simulations are useful for investigating and optimizing a particular reaction process or system. In a article, 1120-95-2, molcular formula is C4H3ClN2, introducing its new discovery.
A series of 5,6-bis(4-substitutedphenyl)-2H(3)-pyridazinones 2a-f have been synthesized from the condensation of the corresponding benzil monohydrazones 1 either with ethyl cyanoacetate or diethyl malonate in ethanol. The synthesized pyridazinones were converted to the corresponding 3-chloro derivatives 3a-f by the action of phosphoryl chloride. Reaction of the latter halogenated pyridazines with various aromatic amines led to the formation of new 3-aminoaryl pyridazines (4) in moderate yield. The structures of all new compounds 2b,c,e,f, 3b-e, 4 were fully identified by the analysis of their 1H and 13C NMR and mass spectra. Some of these synthetic heterocyclic compounds were screened for their antimicrobial activities but they were almost negative.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N408 – PubChem