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4-Amino(alkylamino)-5-chloro-2-substituted-3-oxo-2H-pyridazines and 5-amino(alkylamino, dialkylamino)-4-chloro-2-substituted-3-oxo-2H-pyridazines have been prepared by nucleophilic substitution reactions of 4,5-dichloro-2-substituted-3-oxo-2H-pyridazines with amines in aprotic solvent.Structure of the compounds prepared has been proved by IR and UV spectra.Fungicidal and herbicidal activity of the compounds prepared have been tested.None of the compounds prepared exceeds the standard Vitavax in the fungicidal activity tests.Compounds VIII and XII show equal or better activity on the Hill reaction as compared with the standard pyrazone.
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Reference：
Pyridazine – Wikipedia,
Pyridazine | C4H4N3213 – PubChem